benzodiazepine receptors การใช้

• The benzodiazepine class of drugs also interact with peripheral benzodiazepine receptors.
• Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam.
• Lormetazepam and other benzodiazepine drugs act as positive modulators at the GABA A benzodiazepine receptor complex.
• In particular bretazenil has been proposed to cause a less strong development of GABA A benzodiazepine receptor complexes.
• The transport of norborimide comes from a translocation protein ( TSPO ) also known as peripheral benzodiazepine receptor.
• The subset of GABA A receptors that also bind benzodiazepines are referred to as benzodiazepine receptors ( BzR ).
• It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes.
• Nonbenzodiazepines are molecularly distinct, but nonetheless, they work on the same benzodiazepine receptors and produce similar sedative effects.
• It has similar effects to benzodiazepine drugs, but is structurally distinct and does not bind to the benzodiazepine receptor.
• Additionally, harmane is a monoamine oxidase inhibitor and believed to be the main endogenous ligand for the benzodiazepine receptor.
• However, research continues into other compounds with partial agonist and compounds which are selective for certain GABA A benzodiazepine receptor subtypes.
• W-18 was found to obtain weak activity at both sigma receptors and the translocator protein ( peripheral benzodiazepine receptor ).
• Peripheral benzodiazepine receptors are present in peripheral nervous system tissues, glial cells, and to a lesser extent the central nervous system.
• Benzodiazepines impair learning and memory via their action on benzodiazepine receptors, which causes a dysfunction in the cholinergic neuronal system in mice.
• Long-term use causes adaptive changes in the benzodiazepine receptors, making them less sensitive to stimulation and less powerful in their effects.
• Flurazepam is a unique benzodiazepine in that it is a partial agonist of benzodiazepine receptors whereas other benzodiazepines are full agonists of benzodiazepine receptors.
• Flurazepam is a unique benzodiazepine in that it is a partial agonist of benzodiazepine receptors whereas other benzodiazepines are full agonists of benzodiazepine receptors.
• When lormetazepam binds to the benzodiazepine receptor sites in sufficient quantities it produces sedation which is used clinically as a therapeutic treatment for insomnia.
• Furthermore, disrupted GABA benzodiazepine receptor function is part of alcohol dependence and chronic benzodiazepines may prevent full recovery from alcohol induced mental effects.
• The shift of benzodiazepine receptors to an inverse agonist state after chronic treatment leads the brain to be more sensitive to excitatory drugs or stimuli.